Itraconazole, a Commonly Used Antifungal, Inhibits Fcγ Receptor–Mediated Phagocytosis
نویسندگان
چکیده
منابع مشابه
Calcium spikes in activated macrophages during Fc receptormediated phagocytosis
Rises in intracellular-free calcium ([Ca ]i) have been variously associated with Fc receptor (FcR)-mediated phagocytosis in macrophages. We show here that activation of murine bone marrowderived macrophages increases calcium spiking after FcR ligation. Ratiometric fluorescence microscopy was used to measure [Ca ]i during phagocytosis of immunoglobulin G (IgG)-opsonized erythrocytes. Whereas 13%...
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Microbroth dilution tests in vitro showed the same IC(50) values for itraconazole and hydroxy-itraconazole, within a mode +/- one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with ...
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Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy. We previously reported that disease-relevant anti-glycan autoantibodies inhibited axon regeneration, which echo the clinical association of these antibodies and poor recovery in Guillain-Barré Syndrome. However, the specific molecul...
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Background: Paraquat poisoning is a medical emergency challenge due to its inherent severe toxicity and unavailability of specific antidote for it. In this paper, a series of patients who were treated according to a commonly used treatment flowchart are presented. Methods: This prospective observational study was carried out on paraquat poisoned patients admitted to District Hospital, Chamaraj...
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ژورنال
عنوان ژورنال: Shock
سال: 2014
ISSN: 1073-2322
DOI: 10.1097/shk.0000000000000169